Immunopathogenesis and immunotherapeutic approaches to type 1A diabetes.

Abstract excerpt

It is now clear that type 1A (immune-mediated) diabetes develops in genetically susceptible individuals where, prior to the onset of overt hyperglycaemia, there is usually a long prodrome characterised by the presence of autoimmunity directed at islet beta cells. It is the destruction of these insulin-producing cells that results in loss of metabolic regulation and the resultant hyperglycaemia and severe sequelae...

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