Article
PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression.
Cancer research - 1 Apr 2011
Paraiso Kim H T, Xiang Yun, Rebecca Vito W, Abel Ethan V, Chen Y Ann, Munko A Cecilia, Wood Elizabeth, Fedorenko Inna V, Sondak Vernon K, Anderson Alexander R A, Ribas Antoni, Palma Maurizia Dalla, Nathanson Katherine L, Koomen John M, Messina Jane L, Smalley Keiran S M
Abstract excerpt
This study addresses the role of PTEN loss in intrinsic resistance to the BRAF inhibitor PLX4720. Immunohistochemical staining of a tissue array covering all stages of melanocytic neoplasia (n = 192) revealed PTEN expression to be lost in >10% of all melanoma cases. Although PTEN expression status did not predict for sensitivity to the growth inhibitory effects of PLX4720, it was predictive for apoptosis, with...
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