Article
Beneficial effects of trypsin inhibitors derived from a spider venom peptide in L-arginine-induced severe acute pancreatitis in mice.
PloS one - 1 Jan 2013
Ning Weiwen, Wang Yongjun, Zhang Fan, Wang Hengyun, Wang Fan, Wang Xiaojuan, Tang Huaxin, Liang Songping, Shi Xiaoliu, Liu Zhonghua
Abstract excerpt
HWTI is a 55-residue protein isolated from the venom of the spider Ornithoctonus huwena. It is a potent trypsin inhibitor and a moderate voltage-gated potassium channel blocker. Here, we designed and expressed two HWTI mutants, HWTI-mut1 and HWTI-mut2, in which the potassium channel inhibitory activity was reduced while the trypsin inhibitory activity of the wild type form (approximately 5 EPU/mg) was retained....
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