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Article

Intracellular processing of the paramyxovirus F protein: critical role of the predicted amphipathic alpha helix adjacent to the fusion domain.

Journal of virology - 1 Jul 1992

Wang C, Raghu G, Morrison T, Peeples M E

Abstract excerpt

At a nonpermissive temperature, the group D temperature-sensitive mutants of Newcastle disease virus strain Australia-Victoria (AV) are defective in plaque formation, in inducing infected cells to fuse, and in incorporating the cleaved fusion glycoprotein, F1 + F2, into virus particles. In this study, the F protein of AV, expressed in chicken embryo cells, was able to complement these mutants in a plaque assay,...

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Identifiers

PMID: 1602539
DOI: 10.1128/JVI.66.7.4161-4169.1992
PMCID: PMC241219

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