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Article

A temperature-sensitive mutant of Newcastle disease virus defective in intracellular processing of fusion protein.

Journal of virology - 1 Mar 1990

Matsumura H, Futaesaku Y, Kohno S, Sugiura A, Kohase M

Abstract excerpt

A temperature-sensitive mutant (ts3) of Newcastle disease virus was physiologically characterized. All major viral structural proteins were synthesized at the permissive (37 degrees C) and nonpermissive (42 degrees C) temperatures, but the fusion (F) glycoprotein was not cleaved at 42 degrees C. In immunocytochemical electron microscopy, the F protein was abundant in the rough endoplasmic reticulum but not in...

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Identifiers

PMID: 2304149
DOI: 10.1128/JVI.64.3.1410-1413.1990
PMCID: PMC249268

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