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Article

A temperature-sensitive mutant of Newcastle disease virus defective in intracellular processing of fusion protein.

Journal of virology - 1 Mar 1990

Matsumura H, Futaesaku Y, Kohno S, Sugiura A, Kohase M

Abstract excerpt

A temperature-sensitive mutant (ts3) of Newcastle disease virus was physiologically characterized. All major viral structural proteins were synthesized at the permissive (37 degrees C) and nonpermissive (42 degrees C) temperatures, but the fusion (F) glycoprotein was not cleaved at 42 degrees C. In immunocytochemical electron microscopy, the F protein was abundant in the rough endoplasmic reticulum but not in...

Topics

Animals
Cell Transformation, Viral
Cells, Cultured
Chick Embryo
Defective Viruses
Electrophoresis, Polyacrylamide Gel
Microscopy, Electron
Molecular Weight
Mutation
Newcastle disease virus
Temperature

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Viral Fusion Proteins

Virion

Source

Open in PubMed Open full text

Identifiers

PMID: 2304149
DOI: 10.1128/JVI.64.3.1410-1413.1990
PMCID: PMC249268

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2304149-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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A temperature-sensitive mutant of Newcastle disease virus defective in intracellular processing of fusion protein.PMID 2304149Read ↗

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