Article
The possible role of TP53 mutation status in the treatment of squamous cell carcinomas of the head and neck (HNSCC) with radiotherapy with different overall treatment times.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 Aug 2005
Eriksen Jesper Grau, Alsner Jan, Steiniche Torben, Overgaard Jens
Abstract excerpt
BACKGROUND AND PURPOSE: TP53-mutations have been shown to influence the radiosensitivity of HNSCC. Furthermore, HNSCC with mutated TP53, may have a higher proliferative potential caused by a lack of control in G1 checkpoint. Our aim of the study was to identify the role of TP53 mutations for the outcome of radiotherapy. PATIENTS AND METHODS: DNA extracted from 180 paraffin-embedded formalin-fixed pretreatment...
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