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Advances in biology of multiple myeloma: clinical applications

20 Apr 2004

Abstract excerpt

There appear to be 2 pathways involved in the early pathogenesis of premalignant monoclonal gammopathy of undetermined significance (MGUS) and malignant multiple myeloma (MM) tumors. Nearly half of these tumors are nonhyperdiploid and mostly have immunoglobulin H (IgH) translocations that involve 5 recurrent chromosomal loci, including 11q13 (cyclin D1), 6p21 (cyclin D3), 4p16 (fibroblast growth factor receptor 3...

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Identifiers

PMID: 15090448
DOI: 10.1182/blood-2004-01-0037

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