Article
Complex HTR2C linkage disequilibrium and promoter associations with body mass index and serum leptin.
Human genetics - 1 Oct 2005
McCarthy Shane, Mottagui-Tabar Salim, Mizuno Yumi, Sennblad Bengt, Hoffstedt Johan, Arner Peter, Wahlestedt Claes, Andersson Björn
Abstract excerpt
The occurrence of obesity, eating disorders, and related diseases has increased in many parts of the world. Given that few strong genetic factors have been found, it is clear that these are complex multi-factorial diseases. The serotonin receptor 2C, a member of the 5-HTergic system, has been implicated in the control of phagia and obesity. We report a detailed investigation of linkage disequilibrium (LD) within...
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