Article
The association between plasminogen activator inhibitor type 1 (PAI-1) levels, PAI-1 4G/5G polymorphism, and myocardial infarction: a Mendelian randomization meta-analysis.
Clinical chemistry and laboratory medicine - 1 Jul 2014
Nikolopoulos Georgios K, Bagos Pantelis G, Tsangaris Iraklis, Tsiara Chrissa G, Kopterides Petros, Vaiopoulos Aristides, Kapsimali Violetta, Bonovas Stefanos, Tsantes Argirios E
Abstract excerpt
BACKGROUND: The circulating levels of plasminogen activator inhibitor type 1 (PAI-1) are increased in individuals carrying the 4G allele at position -675 of the PAI-1 gene. In turn, overexpression of PAI-1 has been found to affect both atheroma and thrombosis. However, the association between PAI-1 levels and the incidence of myocardial infarction (MI) is complicated by the potentially confounding effects of...
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