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Article

[SMAD3 inhibits the expression of MMP-2 in mouse embryonic fibroblasts].

Yi chuan xue bao = Acta genetica Sinica - 1 Jun 2005

Mao Chun-Ming, Yang Xiao, Lü Ya-Xin, Sun Yan-Xun, Cheng Xuan, Huang Cui-Fen

Abstract excerpt

SMAD3 is one of the receptor-activated SMADs which are important in TGF-beta signal transduction. Smad3-null mice show accelerated cutaneous wound healing compared with wild-type mice. In this work, we investigated the functions and the mechanism of Smad3-mediated TGF-beta signal on matrix metaloproteinase-2 (MMP-2) in mouse fibroblast. We found that MMP-2 at wound bed was expressed earlier in Smad3-null mice...

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Source

Identifiers

PMID: 16018191

Genes

SMAD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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