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Article

Delayed re-epithelialization in Ppm1a gene-deficient mice is mediated by enhanced activation of Smad2.

The Journal of biological chemistry - 9 Dec 2011

Yang Xue, Teng Yan, Hou Ning, Fan Xiongwei, Cheng Xuan, Li Jun, Wang Lijuan, Wang Youliang, Wu Xiushan, Yang Xiao

Abstract excerpt

Protein phosphatase magnesium-dependent 1A (PPM1A), a protein serine/threonine phosphatase, controls several signal pathways through cleavage of phosphate from its substrates. However, the in vivo function of Ppm1a in mammals remains unknown. Here we reported that mice lacking Ppm1a developed normally but were impaired in re-epithelialization process during cutaneous wound healing. Specifically, complete or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21990361
DOI: 10.1074/jbc.M111.292284
PMCID: PMC3234921

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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