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Article

Pharmacogenomics of tumor necrosis factor antagonists in rheumatoid arthritis.

Pharmacogenomics - 1 Jul 2005

Ranganathan Prabha

Abstract excerpt

Tumor necrosis factor (TNF)-alpha plays a central role in the pathogenesis of rheumatoid arthritis (RA) and is instrumental in causing joint destruction, the clinical hallmark of the disease. Recognizing this, in recent years biological therapies have been developed that work by blocking the damaging effects of TNF-alpha on synovium and cartilage. Three such agents are currently approved for treatment in RA -...

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Identifiers

PMID: 16013998
DOI: 10.2217/14622416.6.5.481

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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