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Lack of resistance development during brincidofovir therapy in animal models of orthopoxvirus infection.

Antiviral research - 1 May 2026

Kammanadiminti Srinivas, Foster Scott, Tugwell Matthew, Morrison Tom, Barker Douglas, Lin Yi-Chan, Shearer Jeffry, Evans David H, Kodihalli Shantha

Abstract excerpt

Brincidofovir (BCV, commercially known as Tembexa®) is an antiviral drug with broad-spectrum activity against double-stranded DNA viruses, including orthopoxviruses. BCV was developed and approved for treating human smallpox in adults and children, including neonates, under the FDA Animal Rule. The efficacy data for licensure were obtained using two surrogate models of smallpox: the rabbitpox virus (RPXV) in New...

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PMID: 41812928
DOI: 10.1016/j.antiviral.2026.106392

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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