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Article

Treatment of Lethal Vaccinia Virus Respiratory Infections in Mice with Cidofovir

1 Feb 2001

Abstract excerpt

Intranasal infection of BALB/c mice with the WR strain of vaccinia virus leads to pneumonia, profound weight loss and death. Five days after intranasal inoculation, virus from untreated mice was recovered from 11 organs, tissues and whole blood. The highest titres [>10(8) plaque forming units (pfu)/g] were in lungs and nose/sinus tissue, with about 10(7) pfu/g in spleen and blood. Seven other organs contained 30-...

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PMID: 11437324
DOI: 10.1177/095632020101200105

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