Lack of antiviral activity of probenecid in Vero E6 cells and Syrian golden hamsters: a need for better understanding of inter-lab differences in preclinical assays

Abstract excerpt

Antiviral interventions are urgently required to support vaccination programmes and reduce the global burden of COVID-19. Prior to initiation of large-scale clinical trials, robust preclinical data in support of candidate plausibility are required. The speed at which preclinical models have been developed during the pandemic are unprecedented but there is a vital need for standardisation and assessment of the Crit...

Topics

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• Animal Disease Management and Epidemiology
• COVID-19 Clinical Research Studies
• Influenza Virus Research Studies
• interferon and immune responses
• Respiratory viral infections research
• SARS-CoV-2 and COVID-19 Research
• Viral gastroenteritis research and epidemiology
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

0321690d-33a4-5a83-bc90-a58b2fb9f457

DOI

10.1101/2022.03.03.482788