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Article

Risk of brain tumors in children and susceptibility to organophosphorus insecticides: the potential role of paraoxonase (PON1).

Environmental health perspectives - 1 Jul 2005

Searles Nielsen Susan, Mueller Beth A, De Roos Anneclaire J, Viernes Hannah-Malia A, Farin Federico M, Checkoway Harvey

Abstract excerpt

Prior research suggests that childhood brain tumors (CBTs) may be associated with exposure to pesticides. Organophosphorus insecticides (OPs) target the developing nervous system, and until recently, the most common residential insecticides were chlorpyrifos and diazinon, two OPs metabolized in the body through the cytochrome P450/paraoxonase 1 (PON1) pathway. To investigate whether two common PON1 polymorphisms,...

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Source

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Identifiers

PMID: 16002382
DOI: 10.1289/ehp.7680
PMCID: PMC1257655

Genes

PON1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Risk of brain tumors in children and susceptibility to organophosphorus insecticides: the potential role of paraoxonase (PON1).PMID 16002382Read ↗

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