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Article

Novel amplifications in pediatric medulloblastoma identified by genome-wide copy number profiling.

Journal of neuro-oncology - 1 Mar 2012

Nord Helena, Pfeifer Susan, Nilsson Pelle, Sandgren Johanna, Popova Svetlana, Strömberg Bo, Alafuzoff Irina, Nistér Monica, Díaz de Ståhl Teresita

Abstract excerpt

Medulloblastoma (MB) is a WHO grade IV, invasive embryonal CNS tumor that mainly affects children. The aggressiveness and response to therapy can vary considerably between cases, and despite treatment, ~30% of patients die within 2 years from diagnosis. Furthermore, the majority of survivors suffer long-term side-effects due to severe management modalities. Several distinct morphological features have been...

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PMID: 21979893
DOI: 10.1007/s11060-011-0716-0

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