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Adult and Pediatric Medulloblastomas Are Genetically Distinct and Require Different Algorithms for Molecular Risk Stratification

18 May 2010

Abstract excerpt

PURPOSE: Medulloblastoma (MB) is the most common malignant brain tumor in children, whereas it rarely presents in adults. We aimed to identify genetic aberrations in 146 adult MBs to evaluate age-dependent differences in tumor biology and adapt age-specific risk stratification models. METHODS: As a screening set, we studied a cohort of 34 adult MBs by using array-based comparative genomic hybridization comparing...

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PMID: 20479417
DOI: 10.1200/jco.2009.25.7121

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