Article
Large-scale screens for cDNAs with in vivo activity.
Novartis Foundation symposium - 1 Jan 2005
Ting Adrian, Lichtenthaler Stefan, Xavier Ramnik, Na Soon-Young, Rabizadeh Shahrooz, Holmes Tara, Seed Brian
Abstract excerpt
The pace of biological investigation has been greatly accelerated by technologies that permit comprehensive inventory of gene expression under diverse conditions. We have been developing and using approaches to understand gene function that are based on functional assessments of gene activity, using automated expression cloning followed by gene knockdown using shRNA or by gene knockout. Some recent developments...
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