Article
The importance of epistatic interactions in the development of autoimmunity.
Novartis Foundation symposium - 1 Jan 2005
Subramanian Srividya, Wakeland Edward K
Abstract excerpt
Genetic predisposition is the main element in susceptibility to a variety of autoimmune diseases, including systemic lupus erythematosus (SLE). Epistatic interactions between susceptibility loci play a major role in the progression of autoimmunity, as our recent work, associating a common haplotype of the SLAM/CD2 receptor family with autoimmune susceptibility in specific genomic contexts, has illustrated....
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