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Article

Functional epistasis on a common MHC haplotype associated with multiple sclerosis.

Nature - 5 Oct 2006

Gregersen Jon W, Kranc Kamil R, Ke Xiayi, Svendsen Pia, Madsen Lars S, Thomsen Allan Randrup, Cardon Lon R, Bell John I, Fugger Lars

Abstract excerpt

Genes in the major histocompatibility complex (MHC) encode proteins important in activating antigen-specific immune responses. Alleles at adjacent MHC loci are often in strong linkage disequilibrium; however, little is known about the mechanisms responsible for this linkage disequilibrium. Here we report that the human MHC HLA-DR2 haplotype, which predisposes to multiple sclerosis, shows more extensive linkage...

Read the complete abstract on PubMed

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Share to CD4-Positive T-Lymphocytes
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Encephalomyelitis, Autoimmune, Experimental

Share to Epistasis, Genetic

Share to Haplotypes

Share to HLA-DR2 Antigen

Share to Linkage Disequilibrium

Share to Multiple Sclerosis

Source

Identifiers

PMID: 17006452
DOI: 10.1038/nature05133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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