Article
Genetic variation, Fcγ receptors, KIRs and infection: the evolution of autoimmunity.
Current opinion in immunology - 1 Dec 2010
Espeli Marion, Niederer Heather A, Traherne James A, Trowsdale John, Smith Kenneth Gc
Abstract excerpt
Recent work has emphasised the marked genetic variability that exists in the Fc receptor locus. This variation can contribute to the risk of autoimmune disease in both mice and humans, but can also have a profound impact on defence against infection. Using FcγRIIB and FcγRIIIB as examples, we dem...
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