Article
MC1R, ASIP, and DNA repair in sporadic and familial melanoma in a Mediterranean population.
Journal of the National Cancer Institute - 6 Jul 2005
Landi Maria Teresa, Kanetsky Peter A, Tsang Shirley, Gold Bert, Munroe David, Rebbeck Timothy, Swoyer Jennifer, Ter-Minassian Monica, Hedayati Mohammad, Grossman Lawrence, Goldstein Alisa M, Calista Donato, Pfeiffer Ruth M
Abstract excerpt
BACKGROUND: Melanoma risk factors include fair pigmentation, multiple nevi, low DNA repair capacity, and CDKN2A or CDK4 mutations. Variants of the melanocortin-1 receptor (MC1R) gene have been associated with fair pigmentation and melanoma risk, and a polymorphism of the Agouti Signaling Protein (ASIP) gene has been associated with dark pigmentation. We examined MC1R and ASIP genotypes in relation to phenotypic...
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