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Article

α-Myosin Heavy Chain

5 Jul 2005

Abstract excerpt

BACKGROUND: Mutations in the beta-myosin heavy-chain (betaMyHC) gene cause hypertrophic (HCM) and dilated (DCM) forms of cardiomyopathy. In failing human hearts, downregulation of alphaMyHC mRNA or protein has been correlated with systolic dysfunction. We hypothesized that mutations in alphaMyHC could also lead to pleiotropic cardiac phenotypes, including HCM and DCM. METHODS AND RESULTS: A cohort of 434...

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Share to Cardiac electrophysiology and arrhythmias
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Identifiers

PMID: 15998695
DOI: 10.1161/circulationaha.104.507699

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