Mutations of the beta myosin heavy chain gene in hypertrophic cardiomyopathy: critical functional sites determine prognosis.

doi:10.1136/heart.89.10.1179

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Mutations of the beta myosin heavy chain gene in hypertrophic cardiomyopathy: critical functional sites determine prognosis.

Heart (British Cardiac Society) - 1 Oct 2003

Woo A, Rakowski H, Liew J C, Zhao M-S, Liew C-C, Parker T G, Zeller M, Wigle E D, Sole M J

Abstract excerpt

OBJECTIVES: To assess patients with different types of mutations of the beta myosin heavy chain (beta MHC) gene causing hypertrophic cardiomyopathy (HCM) and to determine the prognosis of patients according to the affected functional domain of beta MHC. DESIGN AND SETTING: Cohort study of subjects referred to an HCM clinic at an academic hospital. PATIENTS: 70 probands from the HCM clinic were screened for...

Topics

Adolescent
Adult
Age of Onset
Aged
Aged, 80 and over
Cardiomyopathy, Hypertrophic
Child
Cohort Studies
Conserved Sequence
Female
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Middle Aged

Mutation, Missense

Myosin Heavy Chains

Pedigree

Polymorphism, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 12975413
DOI: 10.1136/heart.89.10.1179
PMCID: PMC1767874

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations of the beta myosin heavy chain gene in hypertrophic cardiomyopathy: critical functional sites determine prognosis.PMID 12975413Read ↗

Characteristics and prognostic implications of myosin missense mutations in familial hypertrophic cardiomyopathy.Semantic proximity Read ↗

Familial hypertrophic cardiomyopathy caused by a de novo Gly716Arg mutation of the β-myosin heavy chain.Semantic proximity Read ↗

Sudden cardiac death in hypertrophic cardiomyopathy. Variability in phenotypic expression of beta-myosin heavy chain mutations.Semantic proximity Read ↗

Molecular genetics of hypertrophic cardiomyopathy.Semantic proximity Read ↗

Phenotype and prognostic correlations of the converter region mutations affecting the β myosin heavy chain.Semantic proximity Read ↗

Familial hypertrophic cardiomyopathy and atrial fibrillation caused by Arg663His beta-cardiac myosin heavy chain mutation.Semantic proximity Read ↗

A missense mutation in the beta myosin heavy chain gene is a predictor of premature sudden death in patients with hypertrophic cardiomyopathy.Semantic proximity Read ↗

Missense mutation of the beta-cardiac myosin heavy-chain gene in hypertrophic cardiomyopathy.Semantic proximity Read ↗

Differences in clinical expression of hypertrophic cardiomyopathy associated with two distinct mutations in the beta-myosin heavy chain gene. A 908Leu----Val mutation and a 403Arg----Gln mutation.Semantic proximity Read ↗

α-Myosin Heavy ChainSemantic proximity Read ↗

Skeletal muscle expression and abnormal function of beta-myosin in hypertrophic cardiomyopathy.Semantic proximity Read ↗

Sudden cardiac death in patients with hypertrophic cardiomyopathy: from bench to bedside with an emphasis on genetic markers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.