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Article

Clinical implications of hypertrophic cardiomyopathy associated with mutations in the alpha-tropomyosin gene.

1 Jul 1996

Abstract excerpt

OBJECTIVE: The disease-bearing genes for hypertrophic cardiomyopathy (HCM) in HCM families have been identified as the beta-myosin heavy chain, alpha-tropomyosin, and cardiac troponin T genes. Three HCM kindreds with three distinct point mutations in the alpha-tropomyosin gene had extensive clinical evaluations. DESIGN AND RESULTS: Single-strand conformation polymorphism gel analysis of polymerase chain reaction...

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Identifiers

PMID: 8774330
DOI: 10.1136/hrt.76.1.63

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