Article
Analysis of the polymorphic prion protein gene codon 129 in idiopathic Parkinson's disease.
Journal of neural transmission (Vienna, Austria : 1996) - 1 Mar 2006
Gossrau G, Herting B, Möckel S, Kempe A, Koch R, Reichmann H, Lampe J B
Abstract excerpt
Idiopathic Parkinson's disease (IPD) is a neurodegenerative disorder of unknown aetiology. Histopathological similarities between IPD and Creutzfeldt-Jakob prion disease (CJD) have been suggested. Homozygosity at polymorphic prion protein gene codon 129 (PRNP129) is a risk factor for developing CJD. Therefore we investigated a putative genetic link between CJD and IPD by studying PRNP129 genotype segregation in...
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