Article
Prion protein codon 129 genotype prevalence is altered in primary progressive aphasia.
Annals of neurology - 1 Dec 2005
Li Xiaohong, Rowland Lewis P, Mitsumoto Hiroshi, Przedborski Serge, Bird Thomas D, Schellenberg Gerard D, Peskind Elaine, Johnson Nancy, Siddique Teepu, Mesulam M-Marsel, Weintraub Sandra, Mastrianni James A
Abstract excerpt
The prion protein (PrP) is central to the prion diseases, although a role in other neurodegenerative diseases has been postulated. A common polymorphism (Met or Val) at codon 129 of the PrP gene (PRNP) features prominently in the risk and phenotype, of prion disease, and an abnormality in its distribution frequency may signal a role for PrP in other diseases. We conducted a case-control study to compare the PRNP...
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