Article
Different bacterial cargo in apoptotic cells drive distinct macrophage phenotypes.
Apoptosis : an international journal on programmed cell death - 1 Apr 2024
Salina Ana Carolina Guerta, de Aquino Penteado Letícia, Dejani Naiara Naiana, Silva-Pereira Ludmilla, Raimundo Breno Vilas Boas, Corrêa Gabriel Ferranti, Oliveira Karen Cristina, Ramalho Leandra Naira Zambelli, Boko Mèdéton Mahoussi Michaël, Bonato Vânia L D, Henrique Serezani C, Medeiros Alexandra Ivo
Abstract excerpt
The removal of dead cells (efferocytosis) contributes to the resolution of the infection and preservation of the tissue. Depending on the environment milieu, macrophages may show inflammatory (M1) or anti-inflammatory (M2) phenotypes. Inflammatory leukocytes are recruited during infection, followed by the accumulation of infected and non-infected apoptotic cells (AC). Efferocytosis of non-infected AC promotes...
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