Article
Clonal T-cell response against autologous pleomorphic malignant fibrous histiocytoma antigen presented by retrieved HLA-A*0206.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Feb 2008
Kimura Shigeharu, Kozakai Yuriko, Kawaguchi Satoshi, Tsukahara Tomohide, Ida Kazunori, Murase Masaki, Matsumura Tadaki, Kaya Mitunori, Torigoe Toshihiko, Wada Takuro, Sato Noriyuki, Yamashita Toshihiko
Abstract excerpt
Towards the goal of identifying tumor-rejection antigens on eradicated tumors in bone and soft tissue sarcomas, we evaluated the immune response against antigens presented by lost HLA class I molecules. Tumor specimens and peripheral blood samples were obtained from a 70-year-old woman with pleomorphic malignant fibrous histiocytoma. Over 1-year culture, a tumor cell line (MFH2004) was established. A B-cell line...
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