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Article

Tumor-infiltrating B lymphocytes as a potential source of identifying tumor antigen in human lung cancer.

Cancer research - 15 Mar 2002

Yasuda Manabu, Takenoyama Mitsuhiro, Obata Yuichi, Sugaya Masakazu, So Tomoko, Hanagiri Takeshi, Sugio Kenji, Yasumoto Kosei

Abstract excerpt

Functional studies using freshly isolated tumor-infiltrating B lymphocytes(TIB) are difficult to perform and interpret. Here we document a novel function of TIB using fresh human lung cancer tissues engrafted in SCID mice; they are at activated state and produce tumor-specific antibodies in tumor microenvironment: (a) TIB engrafted in SCID mice produced human IgG; (b) IgG derived from TIB highly bound...

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Identifiers

PMID: 11912150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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