Article
Mannose binding lectin genotypes influence recovery from hepatitis B virus infection.
Journal of virology - 1 Jul 2005
Thio Chloe L, Mosbruger Timothy, Astemborski Jacquie, Greer Spencer, Kirk Gregory D, O'Brien Stephen J, Thomas David L
Abstract excerpt
Mannose binding lectin (MBL) is a central component of the innate immune response and thus may be important for determining hepatitis B virus (HBV) persistence. Since single-nucleotide polymorphisms (SNPs) in the gene encoding MBL (mbl2) alter the level of functional MBL, we hypothesized that mbl2 genotypes are a determinant of HBV persistence or recovery from viral infection. We tested this hypothesis by using a...
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