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Article

The SPI-1 gene of rabbitpox virus determines host range and is required for hemorrhagic pock formation.

Virology - 1 Jul 1994

Ali A N, Turner P C, Brooks M A, Moyer R W

Abstract excerpt

Wild-type rabbitpox virus (RPV) and cowpox virus (CPV) produce red hemorrhagic lesions or pocks upon infection of the chicken chorioallantoic membrane (CAM) of 11-day-old embryonated chicken eggs. However, white, nonhemorrhagic pock variants arise spontaneously within wild-type (wt) populations of either virus at a frequency of about 1%, reflective of complex deletions/rearrangements in the termini of the viral...

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Identifiers

PMID: 8009842
DOI: 10.1006/viro.1994.1347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The SPI-1 gene of rabbitpox virus determines host range and is required for hemorrhagic pock formation.PMID 8009842Read ↗

Suppressors of a host range mutation in the rabbitpox virus serpin SPI-1 map to proteins essential for viral DNA replication.Semantic proximity Read ↗

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A rabbitpox virus serpin gene controls host range by inhibiting apoptosis in restrictive cellsSemantic proximity Read ↗

Triad of human cellular proteins, IRF2, FAM111A, and RFC3, restrict replication of orthopoxvirus SPI-1 host-range mutants.Semantic proximity Read ↗

Vaccinia virus serpins B13R (SPI-2) and B22R (SPI-1) encode M(r) 38.5 and 40K, intracellular polypeptides that do not affect virus virulence in a murine intranasal model.Semantic proximity Read ↗

The cowpox virus SPI-3 and myxoma virus SERP1 serpins are not functionally interchangeable despite their similar proteinase inhibition profiles in vitro.Semantic proximity Read ↗

Deletion of the K145R and DP148R Genes from the Virulent ASFV Georgia 2007/1 Isolate Delays the Onset, but Does Not Reduce Severity, of Clinical Signs in Infected PigsSemantic proximity Read ↗

The Genetic Variation of Porcine Reproductive and Respiratory Syndrome Virus Replicase Protein nsp2 Modulates Viral Virulence and Persistence.Semantic proximity Read ↗

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