Article
Vaccinia virus serpins B13R (SPI-2) and B22R (SPI-1) encode M(r) 38.5 and 40K, intracellular polypeptides that do not affect virus virulence in a murine intranasal model.
Virology - 10 Jan 1995
Kettle S, Blake N W, Law K M, Smith G L
Abstract excerpt
A characterization of genes B13R (SPI-2) and B22R (SPI-1) from vaccinia virus strain Western Reserve (WR) is presented. These genes are transcribed early during infection and the predicted encoded proteins show similarity to the superfamily of serine protease inhibitors (serpins). The 5' transcri...
Topics
- Administration, Intranasal
- Amino Acid Sequence
- Animals
- Base Sequence
- DNA Primers
- Female
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Mutation
- Nasal Mucosa
- Peptides
- Sequence Deletion
- Serpins
- Transcription, Genetic
- Vaccinia
- Vaccinia virus
- Viral Proteins