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Article

Novel human monoclonal antibody combination effectively neutralizing natural rabies virus variants and individual in vitro escape mutants.

Journal of virology - 1 Jul 2005

Bakker Alexander B H, Marissen Wilfred E, Kramer R Arjen, Rice Amy B, Weldon William C, Niezgoda Michael, Hanlon Cathleen A, Thijsse Sandra, Backus Harold H J, de Kruif John, Dietzschold Bernhard, Rupprecht Charles E, Goudsmit Jaap

Abstract excerpt

The need to replace rabies immune globulin (RIG) as an essential component of rabies postexposure prophylaxis is widely acknowledged. We set out to discover a unique combination of human monoclonal antibodies (MAbs) able to replace RIG. Stringent criteria concerning neutralizing potency, affinity, breadth of neutralization, and coverage of natural rabies virus (RV) isolates and in vitro escape mutants were set...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15994800
DOI: 10.1128/JVI.79.14.9062-9068.2005
PMCID: PMC1168753

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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