Article
Negative effects of a disulfide bond mismatch in anti-rabies G protein single-chain antibody variable fragment FV57.
Molecular immunology - 1 Jun 2014
Duan Ye, Gu Tiejun, Zhang Xizhen, Jiang Chunlai, Yuan Ruosen, Li Zhuang, Wang Dandan, Chen Xiaoxu, Wu Chunlai, Chen Yan, Wu Yongge, Kong Wei
Abstract excerpt
Rabies virus (RV) causes a fatal infectious disease requiring efficient post-exposure prophylaxis (PEP), which includes a rabies vaccine and rabies immunoglobulin (RIG). The single-chain antibody variable fragment (scFv), a small engineered antibody fragment derived from an antibody variable heavy chain and light chain, has the potential to replace the current application of RIG. In previous studies, we...
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