Article
An amino acid change in the DNA-binding region of Sry, found in Mus musculus domesticus and other species, does not explain C57BL/6J-YDOM sex-reversal.
Biochemical and biophysical research communications - 29 May 1992
Graves P E, Erickson R P
Abstract excerpt
Sry is the testes determining factor gene located on the Y chromosome. We have performed dideoxy sequencing or restriction enzyme digestion of Sry sequences amplified by PCR from a variety of inbred strains and species of mice. A nonconservative replacement of Thr for Isoleu at position 61 was fo...
Topics
- Animals
- Base Sequence
- Crosses, Genetic
- DNA-Binding Proteins
- Disorders of Sex Development
- Genes, Dominant
- Mice
- Molecular Sequence Data
- Muscidae
- Mutation
- Nuclear Proteins
- Sequence Homology, Nucleic Acid
- Sex Determination Analysis
- Sex-Determining Region Y Protein
- Transcription Factors