Article
Testis-determining factor and Y-linked sex reversal.
Current opinion in genetics & development - 1 Jun 1991
Hawkins J R, Koopman P, Berta P
Abstract excerpt
A gene named SRY, isolated last year from the sex-determining region of the human Y chromosome, satisfies many of the criteria expected of the testis-determining factor gene. Mutations in SRY have been found in XY females, strongly implicating SRY as the testis-determining gene.
Topics
- Animals
- DNA-Binding Proteins
- Disorders of Sex Development
- Female
- Genetic Linkage
- Humans
- Kruppel-Like Transcription Factors
- Male
- Mice
- Mutation
- Nuclear Proteins
- Sex Determination Analysis
- Sex-Determining Region Y Protein