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Article

Genetic evidence equating SRY and the testis-determining factor.

Nature - 29 Nov 1990

Berta P, Hawkins J R, Sinclair A H, Taylor A, Griffiths B L, Goodfellow P N, Fellous M

Abstract excerpt

The testis-determining factor gene (TDF) lies on the Y chromosome and is responsible for initiating male sex determination. SRY is a gene located in the sex-determining region of the human and mouse Y chromosomes and has many of the properties expected for TDF. Sex reversal in XY females results...

Topics

Amino Acid Sequence
Animals
Base Sequence
DNA-Binding Proteins
Disorders of Sex Development
Humans
Kruppel-Like Transcription Factors
Mice
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rabbits

Sex Determination Analysis

Transcription Factors

Y Chromosome

Source

Identifiers

PMID: 2247149
DOI: 10.1038/348448A0

Genes

SRY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2247149-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Genetic evidence equating SRY and the testis-determining factor.PMID 2247149Read ↗

Mutational analysis of SRY: nonsense and missense mutations in XY sex reversal.Semantic proximity Read ↗

Mutational analysis of SRY in XY females.Semantic proximity Read ↗

Analysis of the sex-determining region of the Y chromosome (SRY) in sex reversed patients: point-mutation in SRY causing sex-reversion in a 46,XY female.Semantic proximity Read ↗

Evidence for increased prevalence of SRY mutations in XY females with complete rather than partial gonadal dysgenesis.Semantic proximity Read ↗

Three novel SRY mutations in XY gonadal dysgenesis and the enigma of XY gonadal dysgenesis cases without SRY mutations.Semantic proximity Read ↗

Analysis of the testis-determining gene SRY in patients with XY gonadal dysgenesis.Semantic proximity Read ↗

Testis-determining factor and Y-linked sex reversal.Semantic proximity Read ↗

Familial case with sequence variant in the testis-determining region associated with two sex phenotypes.Semantic proximity Read ↗

A human XY female with a frame shift mutation in the candidate testis-determining gene SRY.Semantic proximity Read ↗

Familial Sex Reversal: A ReviewSemantic proximity Read ↗

Candidate genes in complete and partial XY sex reversal: mutation analysis of SRY, SRY-related genes and FTZ-F1.Semantic proximity Read ↗

Abnormalities of human sex determination.Semantic proximity Read ↗

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