Article
DNA sequence analysis of Sry alleles (subgenus Mus) implicates misregulation as the cause of C57BL/6J-Y(POS) sex reversal and defines the SRY functional unit.
Genetics - 1 Nov 1997
Albrecht K H, Eicher E M
Abstract excerpt
The Sry (sex determining region, Y chromosome) open reading frame from mice representing four species of the genus Mus was sequenced in an effort to understand the conditional dysfunction of some M. domesticus Sry alleles when present on the C57BL/6J inbred strain genetic background and to delimit the functionally important protein regions. Twenty-two Sry alleles were sequenced, most from wild-derived Y...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- DNA, Complementary
- DNA-Binding Proteins
- Disorders of Sex Development
- Female
- Male
- Mice
- Mice, Inbred C57BL
- Molecular Sequence Data
- Nuclear Proteins
- Open Reading Frames
- Polymorphism, Genetic