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Article

Long-term monitoring of bacteria undergoing programmed population control in a microchemostat.

Science (New York, N.Y.) - 1 Jul 2005

Balagaddé Frederick K, You Lingchong, Hansen Carl L, Arnold Frances H, Quake Stephen R

Abstract excerpt

Using an active approach to preventing biofilm formation, we implemented a microfluidic bioreactor that enables long-term culture and monitoring of extremely small populations of bacteria with single-cell resolution. We used this device to observe the dynamics of Escherichia coli carrying a synthetic "population control" circuit that regulates cell density through a feedback mechanism based on quorum sensing. The...

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Identifiers

PMID: 15994559
DOI: 10.1126/science.1109173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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