Article
Microfluidic Evolution-On-A-Chip Reveals New Mutations that Cause Antibiotic Resistance.
Small (Weinheim an der Bergstrasse, Germany) - 1 Mar 2021
Zoheir Ahmed E, Späth Georg P, Niemeyer Christof M, Rabe Kersten S
Abstract excerpt
Microfluidic devices can mimic naturally occurring microenvironments and create microbial population heterogeneities ranging from planktonic cells to biofilm states. The exposure of such populations to spatially organized stress gradients can promote their adaptation into complex phenotypes, which are otherwise difficult to achieve with conventional experimental setups. Here a microfluidic chip that employs...
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