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Article

Structural and chemical requirements for histidine phosphorylation by the chemotaxis kinase CheA.

The Journal of biological chemistry - 26 Aug 2005

Quezada Cindy M, Hamel Damon J, Gradinaru Cristian, Bilwes Alexandrine M, Dahlquist Frederick W, Crane Brian R, Simon Melvin I

Abstract excerpt

The CheA histidine kinase initiates the signal transduction pathway of bacterial chemotaxis by autophosphorylating a conserved histidine on its phosphotransferase domain (P1). Site-directed mutations of neighboring conserved P1 residues (Glu-67, Lys-48, and His-64) show that a hydrogen-bonding network controls the reactivity of the phospho-accepting His (His-45) in Thermotoga maritima CheA. In particular, the...

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Source

Identifiers

PMID: 15994328
DOI: 10.1074/jbc.M505316200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structural and chemical requirements for histidine phosphorylation by the chemotaxis kinase CheA.PMID 15994328Read ↗

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