Article
Structure of the entire cytoplasmic portion of a sensor histidine-kinase protein.
The EMBO journal - 21 Dec 2005
Marina Alberto, Waldburger Carey D, Hendrickson Wayne A
Abstract excerpt
The large majority of histidine kinases (HKs) are multifunctional enzymes having autokinase, phosphotransfer and phosphatase activities, and most of these are transmembrane sensor proteins. Sensor HKs possess conserved cytoplasmic phosphorylation and ATP-binding kinase domains. The different enzymatic activities require participation by one or both of these domains, implying the need for different conformational...
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