Article
Localized perturbations in CheY structure monitored by NMR identify a CheA binding interface.
Nature structural biology - 1 Oct 1995
Swanson R V, Lowry D F, Matsumura P, McEvoy M M, Simon M I, Dahlquist F W
Abstract excerpt
Phosphotransfer between the autophosphorylating histidine kinase CheA and the response regulator CheY represents a crucial step in the bacterial chemotaxis signal transduction pathway. The 15N-1H correlation spectrum of CheY complexed with an amino-terminal fragment of CheA exhibits specific loca...
Topics
- Bacterial Proteins
- Binding Sites
- Chemotaxis
- Escherichia coli
- Escherichia coli Proteins
- Histidine Kinase
- Magnetic Resonance Spectroscopy
- Membrane Proteins
- Methyl-Accepting Chemotaxis Proteins
- Models, Molecular
- Mutation
- Phosphorylation
- Protein Conformation
- Protein Kinases