Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FGF suppresses apoptosis and induces differentiation of fibre cells in the mouse lens.

Development (Cambridge, England) - 1 Dec 1995

Chow R L, Roux G D, Roghani M, Palmer M A, Rifkin D B, Moscatelli D A, Lang R A

Abstract excerpt

To determine whether fibroblast growth factor (FGF) has a role in lens development, we have generated transgenic mice expressing a dominant-negative form of the murine FGF receptor-1 (FGFRDN) in the lens. Using the fibre cell-specific alpha A-crystallin promoter to express the FGFRDN, we have asked whether FGF is required for fibre cell differentiation. The transgenic mice display diminished differentiation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Epithelium
Share to Fibroblast Growth Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Phenotype

Share to Receptors, Fibroblast Growth Factor

Share to Signal Transduction

Source

Identifiers

PMID: 8575338
DOI: 10.1242/dev.121.12.4383

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FGF suppresses apoptosis and induces differentiation of fibre cells in the mouse lens.PMID 8575338Read ↗

Disruption of lens fiber cell differentiation and survival at multiple stages by region-specific expression of truncated FGF receptors.Semantic proximity Read ↗

Persistent FoxE3 expression blocks cytoskeletal remodeling and organelle degradation during lens fiber differentiation.Semantic proximity Read ↗

Expression of a truncated FGF receptor results in defective lens development in transgenic mice.Semantic proximity Read ↗

Requirement for TGFβ receptor signaling during terminal lens fiber differentiationSemantic proximity Read ↗

Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation.Semantic proximity Read ↗

An apoptotic defect in lens differentiation caused by human p53 is rescued by a mutant allele.Semantic proximity Read ↗

Disruption of muscle membrane and phenotype divergence in two novel mouse models of dysferlin deficiency.Semantic proximity Read ↗

Role of the executioner caspases during lens development.Semantic proximity Read ↗

Fibroblast growth factor receptor 1 (Fgfr1) is not essential for lens fiber differentiation in mice.Semantic proximity Read ↗

Activated Ras induces lens epithelial cell hyperplasia but not premature differentiation.Semantic proximity Read ↗

Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival.Semantic proximity Read ↗

Beta-1 integrin is important for the structural maintenance and homeostasis of differentiating fiber cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.