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Article

Life span is related to the free energy of mitochondrial DNA.

Mechanisms of ageing and development - 1 Oct 2005

Samuels David C

Abstract excerpt

Broadly speaking, the mitochondrial theory of aging relates aging to the rate of damage to mitochondria. In this work, I concentrate on a DNA sequence property, the free energy, which can be interpreted as a factor in the susceptibility of mitochondrial DNA (mtDNA) to mutation. I show that life spans across a broad range of species are a function of the mtDNA free energy and are proportional to the probability of...

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Identifiers

PMID: 15992863
DOI: 10.1016/j.mad.2005.05.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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