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Article

Thermodynamic stability explains the differential evolutionary dynamics of cytochrome b and COX I in mammals.

Journal of molecular evolution - 1 Feb 2012

Aledo Juan Carlos, Valverde Héctor, Ruíz-Camacho Manuel

Abstract excerpt

By using a combination of evolutionary and structural data from 231 species, we have addressed the relationship between evolution and structural features of cytochrome b and COX I, two mtDNA-encoded proteins. The interior of cytochrome b, in contrast to that of COX I, exhibits a remarkable tolerance to changes. The higher evolvability of cytochrome b contrasts with the lower rate of synonymous substitutions of...

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Identifiers

PMID: 22362464
DOI: 10.1007/s00239-012-9489-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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