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1267 HSP70-2 polymorphism as a risk factor for carotid plaque rupture and cerebral ischaemia in old type 2 diabetes-atherosclerotic patients.

Mechanisms of ageing and development - 1 Aug 2005

Giacconi Robertina, Caruso Calogero, Lio Domenico, Muti Elisa, Cipriano Catia, Saba Vittorio, Boccoli Gianfranco, Gasparini Nazzarena, Malavolta Marco, Mocchegiani Eugenio

Abstract excerpt

Patients with type 2 diabetes mellitus (NIDDM) are at risk for macrovascular disease complications, such as myocardial infarction (MI) or stroke from plaque rupture. Cytokines play a key role in plaque vulnerability. IFN-gamma inhibits collagen synthesis thereby affecting plaque stability. High IL-6, TNF-alpha, and dyslipidemia are risk factors for thrombosis. Abnormal increments of HSP70 in atherosclerotic...

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PMID: 15992611
DOI: 10.1016/j.mad.2005.03.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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