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Article

Tag polymorphisms at the A20 (TNFAIP3) locus are associated with lower gene expression and increased risk of coronary artery disease in type 2 diabetes.

Diabetes - 1 Feb 2007

Boonyasrisawat Watip, Eberle Delphine, Bacci Simonetta, Zhang Yuan-Yuan, Nolan David, Gervino Ernest V, Johnstone Michael T, Trischitta Vincenzo, Shoelson Steven E, Doria Alessandro

Abstract excerpt

A20 or tumor necrosis factor (TNF)-induced protein 3 (TNFAIP3) is a negative regulator of nuclear factor-kappaB (NF-kappaB). We have investigated whether polymorphisms in this gene are associated with increased atherosclerosis in diabetic patients. Five tag single nucleotide polymorphisms (SNPs) were typed in 479 type 2 diabetic patients from Boston, including 239 coronary artery disease (CAD)-positive case...

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Source

Identifiers

PMID: 17259397
DOI: 10.2337/db06-0946

Genes

CAD
TNFAIP3
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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